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Exploring How Neurons Talk Each Other

 SYNAPTIC COMMUNICATION LABORATORY

Our research aims to understand the concepts and mechanisms which underlie the complexities of the Brain. We use state-of-the-art technologies to explore how neurons connect and communicate with each other, how this connection

and communication are altered in neural diseases.

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            Research

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NEURAL COMMUNICATION AND ITS REGULATION AT SYNAPSES

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We are interested in studying the Neuron and Synapses

which shape and guide the processes of the Brain.

Our long-term goal is to understand the underlying mechanism

of How neurons communicate with each other through Synapses.

 

Our major questions in research

  • How do neurons are connected in networks?

  • How do they communicate with each other once connected? 

  • How do neural diseases alter this basic functionality? 

 

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OPTO-PHYSIOLOGY

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Live-cell trace for synaptic physiology

 

Synaptic vesicle fusion and retrieval using a pHluorin-based assay, Calcium sensor, and other fluorescence sensors combined with a high-fidelity custom-built microscope system

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HIGH FIDELITY LIVE IMAGING

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To monitor  synaptic physiology with high accuracy, 
We utilize a custom-built laser illuminating imaging system.
It leads us to observe various synaptic events from a single synaptic vesicle at the millisecond scale.

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Want to learn more about our research projects?

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People

A COLLABORATIVE & DIVERSE GROUP

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SUNG HYUN KIM, PH.D

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WON KYUNG LEE

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SUKMIN HAN

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YOUNG OK JO

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SOOJI LEE

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NEURON

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MICROSCOPY

Media & Other Important Stuff

2021 고솔미 석사학위 논문 "우수 학위 논문상" 수상

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2020 이원경 학생 논문 한빛사에

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2018 경재원 박사 학위 논문 "최우수 학위 논문상" 수상

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OPEN for A New Student and Post-Doc!
-연구실에 함께 할 대학원생과 포스트 닥을 기다립니다.
궁금한 사항은 언제든지 이메일로 문의하세요

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Publications

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Neural stem cells derived from human midbrain organoids as a stable source for treating Parkinson's disease: Midbrain organoid-NSCs (Og-NSC) as a stable source for PD treatment

Prog Neurobiol​. 2021 Sep;204:102086. doi: 10.1016/j.pneurobio.2021.102086. Epub 2021 May 28.

Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons

Mol Brain Mar16  2021

O-GlcNAcylation ameliorates the pathologic manifestations of Alzheimer's disease by inhibiting necroptosis

Sci Adv Jan13  2021

DISTINCT SYNAPTIC VESICLE RECYCLING IN INHIBITORY NERVE TERMINALS IS COORDINATED BY SV2A

PROG NEUROBIOL JUNE 29 2020

Jae Ryul Bae, Wongyoung Lee, Young Ok Jo, Sukmin Han, Soulmee Koh, Woo Keun Song, Sung Hyun Kim

RECENT ADVANCES IN TWO-PHOTON ABSORBING PROBES BASED ON A FUNCTIONALIZED DIPOLAR NAPHTHALENE PLATFORM

ORG BIOMOL CHEM 2020 APR 3

Jong Min An, Sung Hyun Kim*, Dokyoung Kim*

OPTICAL MEASUREMENT OF SYNAPTIC VESICLE FUSION AND ITS INHIBITION BY INOSITOL PYROPHOSPHATE IN PRIMARY CULTURED HIPPOCAMPAL NEURONS

METHODS IN MOLECULAR BIOLOGY JANUARY, 2020

Sung Hyun Kim

SPIN90, AN ADAPTOR PROTEIN, ALTERS THE PROXIMITY BETWEEN RAB5 AND GAPEX5 AND FACILITATES RAB5 ACTIVATION DURING EGF ENDOCYTOSIS.

EXP MOL MED. 2019 JUL 29;51(7):85. DOI: 10.1038/S12276-019-0284-5.

Kim H, Oh H, Oh YS, Bae J, Hong NH, Park SJ, Ahn S, Lee M, Rhee S, Lee SH, Jun Y, Kim SH, Huh YH, Song WK.

AUTOPHAGY AT SYNAPSES IN NEURODEGENERATIVE DISEASES

ARCH PHARM RES. 2019 MAY;42(5):407-415.

Lee W, Kim SH

CEREBLON MAINTAINS SYNAPTIC AND COGNITIVE FUNCTION BY REGULATING BK CHANNEL

J NEUROSCI 2018 APR 4;38(14):3571-3583.

Choi T-Y, Lee S-H, Kim Y-J, Bae JR, Lee KM, Jo Y, Kim S-J, Lee A, Choi S, Choi L-M, Bang S, Song M-R, Chung J, Lee KJ, Kim SH, Park C-S, Choi S-Y

DJ-1 DEFICIENCY IMPAIRS SYNAPTIC VESICLE ENDOCYTOSIS AND REAVAILABILITY AT NERVE TERMINALS

PNAS 2018 FEB 13;115(7):1629-1634.

Kyng JW*, Kim J*, Lee W. Ha T, Cha S, Chung K, Choi D, Jou I, Song WK, Joe E, Kim SH#, Park SM# (co-corresponding)

SYNAPSES IN NEURODEGENERATIVE DISEASES

BMB REPORTS 2017 MAY;50(5):237-246.

Bae JR, Kim SH.

INHIBITION OF DRP1 AMELIORATES SYNAPTIC DEPRESSION, A BETA DEPOSITION AND COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE MODEL

J NEUROSCI  2017 MAY 17;37(20):5099-5110. DOI: 10.1523/JNEUROSCI.2385-16.2017.

Baek SH*, Park SJ*, Jeong JI*, Kim SH*, Han J, Kyung JW, Baik S, Choi Y, Choi B, Park J, Bahn G, Shin JH, Jo DS, Lee J, Jang C, Arumugam T, Kim J, Han J, Koh J, Cho D, and Jo D

ADAPTOR PROTEIN2(AP-2) COMPLEX IS ESSENTIAL FOR FUNCTIONAL AXOGENESIS IN HIPPOCAMPAL NEURONS.

SCI REP  2017 JAN 31;7:41620. DOI:10.1038/SREP41620

Kyung JW, Cho IH, Lee S, Song WK, Ryan TA, Hoppa MB, Kim SH.

EPSIN1 MODULATES SYNAPTIC VESICLE RETRIEVAL CAPACITY AT CNS SYNAPSES.

SCI REP 2016 AUG 25;6:31997

Kyung JW, Bae JR, Kim D-H, Song WK, Kim SH.

IMPAIRMENT OF SOD1-G93A MOTILITY IS LINKED TO MITOCHONDRIAL MOVEMENT IN AXONS OF HIPPOCAMPAL NEURONS.

ARCHIV PHARM RES 2016 AUG ;39(8):1144-50

Bae JR, Kim SH.

 INOSITOL PYROPHOSPHATES INHIBIT SYNAPTOTAGMIN-DEPENDENT EXOCYTOSIS.

PROC NATL ACAD SCI U S A2016 JUL 19; 113(29):8314-9

Lee TS, Lee JY, Kyung JW, Yang Y, Park SJ, Lee S, Pavlovic I, Kong B, Jho YS, Jessen HJ, Kweon DH, Shin YK, Kim SH*, Yoon TY*, Kim S*.(*co-corresponding)

THE SCHIZOPHRENIA SUSCEPTIBILITY GENE PPP3CC ENCODES A PRESYNAPTIC CALCINEURIN CATALYTIC SUBUNIT THAT MODULATES SYNAPTIC VESICLE CYCLING.

J BIOL CHEM 2016. JAN 22, 291(4) 1948-1956

Cottrell JR, Li B, Kyung JW, Ashford CA, Mann JJ, Horvath T, Ryan TA, Kim SH*, Gerber DJ*. (* co-corresponding)

 BECLIN-1 KNOCKDOWN SHOWS ABSCISSION FAILURE BUT NOT AUTOPHAGY DEFECT DURING OOCYTE MEIOTIC MATURATION.

CELL CYCLE, 2016. JUN 17:15(12):1611-9

You SY, Park YS, Jeon HJ, Cho DH, Jeon HB, Kim SH, Chang JW, Kim JS, Oh JS.

 TRPV1 ON ASTROCYTES RESCUES NIGRAL DOPAMINE NEURONS IN PARKINSON'S DISEASE VIA CNTF. 

BRAIN 2015 DEC; 138(PT 12):3610-22

Nam JH, Park ES, Won SY, Lee YA, Kim KI, Jeong JY, Baek JY, Cho EJ, Jin M, Chung YC, Lee BD, Kim SH, Kim EG, Byun K, Lee B, Woo DH, Lee CJ, Kim SR, Bok E, Kim YS, Ahn TB, Ko HW, Brahmachari S, Pletinkova O, Trochonso JC, Dawson VL, Dawson TM, Jin BK.

GDF-15 SECRETED FROM HUMAN UMBILICAL CORD BLOOD MESENCHYMAL STEM CELLS DELIVERED VIA CSF PROMOTE HIPPOCAMPAL NEUROGENESIS AND SYNAPTIC ACTIVITY IN AN ALZHEIMER'S DISEASE MODEL.

STEM CELLS DEV 2015, JUL 8

Kim DH, Lee D, Chang EH, Kim JH, Hwang JW, Kim JY, Kyung JW, Kim SH, Oh JS, Shim SM, Na DL, Oh W, Chang JW.

SUPPRESSION OF CPN10 INCREASES MITOCHONDRIAL FISSION AND DYSFUNCTION IN NEUROBLASTOMA CELLS.

PLOS ONE 2014, NOV 12;9(11):E112130.

Park SJ, Jo DS, Shin JH, Kim ES, Jo YK, Choi ES, Seo HM, Kim SH, Hwang JJ, Jo DG, Koh JY, Cho DH.

Contact Us

Thanks for your interest in our research. Get in touch with us for any questions or comments regarding our work and publications. We’d love to hear from you.

26 Kyungheedae-ro, Dongdaemun-gu, Seoul, South Korea

Lab +82-2-961-9585, Office +82-2-961-0286

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